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Elizabeth P Henske Selected Research

Tuberous Sclerosis (Bourneville's Disease)

1/2022ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells.
1/2022Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis.
12/2021TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism.
10/2021Renal Cell Carcinoma in Tuberous Sclerosis Complex.
1/2021TSC2 Interacts with HDLBP/Vigilin and Regulates Stress Granule Formation.
1/2021Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex.
1/2021Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex.
1/2021The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back.
1/2021MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61.
1/2021Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.
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Elizabeth P Henske Research Topics

Disease

58Tuberous Sclerosis (Bourneville's Disease)
01/2022 - 03/2002
46Neoplasms (Cancer)
01/2022 - 03/2002
43Lymphangioleiomyomatosis (Lymphangiomyomatosis)
01/2022 - 12/2002
20Angiomyolipoma
10/2021 - 03/2002
12Renal Cell Carcinoma (Grawitz Tumor)
10/2021 - 01/2007
10Lung Diseases (Lung Disease)
01/2022 - 11/2012
9Carcinogenesis
01/2021 - 01/2012
8Cysts
10/2021 - 01/2009
6Neoplasm Metastasis (Metastasis)
01/2019 - 11/2005
3Disease Progression
01/2022 - 01/2018
3Carcinoma (Carcinomatosis)
12/2019 - 01/2007
3Seizures (Absence Seizure)
11/2018 - 12/2002
3Pneumothorax
01/2018 - 05/2017
2Kidney Neoplasms (Kidney Cancer)
10/2021 - 01/2018
2Astrocytoma (Pilocytic Astrocytoma)
01/2021 - 01/2016
2Lung Injury
01/2021 - 11/2018
2Autistic Disorder (Autism)
11/2018 - 12/2002
2Inborn Genetic Diseases (Disease, Hereditary)
01/2018 - 02/2014
2Hyperplasia
01/2018 - 01/2012
2Hypoxia (Hypoxemia)
03/2016 - 12/2009
2Perivascular Epithelioid Cell Neoplasms
01/2016 - 10/2014
1Shock
01/2021
1Surfactant Dysfunction
01/2021
1COVID-19
01/2021
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2021
1Pneumonia (Pneumonitis)
01/2021
1Renal Insufficiency (Renal Failure)
01/2021
1Ventilator-Induced Lung Injury
01/2021
1Lymphatic Abnormalities
12/2019
1Adenoma (Adenomas)
01/2019
1Rheumatoid Arthritis
11/2018
1Dyspnea (Shortness of Breath)
01/2018
1Urinary Bladder Neoplasms (Bladder Cancer)
01/2018
1Pleural Effusion (Pleural Effusions)
01/2018

Drug/Important Bio-Agent (IBA)

51trans-sodium crocetinate (crocetin)IBA
12/2021 - 12/2002
32lipoarabinomannan (LAM)IBA
01/2022 - 02/2009
28Mechanistic Target of Rapamycin Complex 1IBA
01/2022 - 01/2012
18Sirolimus (Rapamycin)FDA Link
01/2021 - 06/2006
12Proteins (Proteins, Gene)FDA Link
01/2021 - 04/2003
10TOR Serine-Threonine KinasesIBA
12/2019 - 04/2003
8RNA (Ribonucleic Acid)IBA
01/2022 - 12/2004
5MTOR InhibitorsIBA
01/2020 - 06/2006
5Phosphotransferases (Kinase)IBA
03/2016 - 01/2007
4Biomarkers (Surrogate Marker)IBA
01/2022 - 01/2018
4Glutathione (Reduced Glutathione)IBA
12/2020 - 01/2017
4Tuberous Sclerosis Complex 2 ProteinIBA
02/2009 - 12/2002
3Estrogens (Estrogen)FDA Link
11/2016 - 02/2009
3DNA (Deoxyribonucleic Acid)IBA
03/2016 - 06/2006
2Transcription Factors (Transcription Factor)IBA
10/2021 - 01/2021
2NucleotidesIBA
01/2020 - 11/2017
2MicroRNAs (MicroRNA)IBA
12/2019 - 01/2013
2NestinIBA
01/2019 - 11/2017
2Vascular Endothelial Growth Factor DIBA
01/2018 - 01/2017
2TransferasesIBA
01/2018 - 04/2008
2Ribosomal Protein S6IBA
04/2008 - 06/2006
270-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA
06/2006 - 04/2003
1Peptide Hydrolases (Proteases)FDA Link
01/2022
1Messenger RNA (mRNA)IBA
01/2022
1Lipid NanoparticlesIBA
01/2022
1Therapeutic UsesIBA
01/2022
1arseniteIBA
01/2021
1AcidsIBA
01/2021
1Carbonic Anhydrases (Carbonic Anhydrase)IBA
01/2021
1ChromatinIBA
01/2021
1ElectrolytesIBA
01/2021
1Proton-Translocating ATPases (ATPase, H+)IBA
01/2021
1Phospholipids (Phosphatides)FDA LinkGeneric
01/2021
1Serine (L-Serine)FDA Link
01/2021
1Surface-Active Agents (Surfactants)IBA
01/2021
1Interleukin-6 (Interleukin 6)IBA
01/2021
1CytokinesIBA
01/2021
1RitanserinIBA
01/2021
1Protein Isoforms (Isoforms)IBA
01/2021
1Microphthalmia-Associated Transcription FactorIBA
01/2021
1Forkhead Transcription Factors (Forkhead Box Proteins)IBA
01/2021
1mizoribineIBA
01/2020
1CarcinogensIBA
01/2020
1Oxidoreductases (Dehydrogenase)IBA
01/2020
1Protein Kinases (Protein Kinase)IBA
01/2020
1Celecoxib (Celebrex)FDA Link
01/2020
1EnzymesIBA
01/2020
1RetinoidsIBA
12/2019
1AntibodiesIBA
12/2019
1mouse MIRN29 microRNAIBA
12/2019
1PolyaminesIBA
12/2019
1Retinoic Acid Receptors (Retinoic Acid Receptor)IBA
12/2019
1Programmed Cell Death 1 ReceptorIBA
12/2019
1Adenosine Triphosphate (ATP)IBA
01/2019
1vistusertibIBA
01/2019
1Codon (Codons)IBA
01/2019
1EndostatinsIBA
01/2019
1Arginine (L-Arginine)FDA Link
01/2019
1Proline (L-Proline)FDA Link
01/2019
1Vitamin D-Binding ProteinIBA
11/2018
1Hydroxychloroquine (Plaquenil)FDA LinkGeneric
11/2018
1Cytokine Receptors (Cytokine Receptor)IBA
11/2018
1Oxygen (Dioxygen)IBA
01/2018

Therapy/Procedure

11Therapeutics
01/2022 - 03/2002
2Immunotherapy
12/2019 - 01/2018
1Aftercare (After-Treatment)
11/2018